BIRC2 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : API 1 antibody; API1 antibody; Apoptosis inhibitor 1 antibody; Bac µLoviral IAP repeat containing 2 antibody; Bac µLoviral IAP repeat containing protein 2 antibody; Bac µLoviral IAP repeat-containing protein 2 antibody; BIRC 2 antibody; BIRC2 antibody; BIRC2_HUMAN antibody; C IAP1 antibody; C-IAP1 antibody; Cell µLar inhibitor of apoptosis 1 antibody; cell µLar inhibitor of apoptosis protein 1 antibody; cIAP 1 antibody; cIAP1 antibody; HIAP 2 antibody; HIAP-2 antibody; HIAP2 antibody; IAP 2 antibody; IAP homolog B antibody; IAP-2 antibody; IAP2 antibody; Inhibitor of apoptosis protein 2 antibody; MIHB antibody; NFR2 TRAF signalling complex protein antibody; RING finger protein 48 antibody; RNF 48 antibody; RNF48 antibody; TNFR2 TRAF signaling complex protein 2 antibody; TNFR2-TRAF-signaling complex protein 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13490
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 2 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1 IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conj µgation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stim µLate the transcriptional activity of E2F1. Plays a role in the mod µLation of the cell cycle.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC2
Research Areas : Cancer; Cell biology; Metabolism