BRD8 Antibody Biotin conjugated
Volume : 50 µg
Clone Number :
Aliases : BRD8 antibody; SMAP antibody; SMAP2 antibody; Bromodomain-containing protein 8 antibody; Skeletal muscle abundant protein antibody; Skeletal muscle abundant protein 2 antibody; Thyroid hormone receptor coactivating protein of 120 kDa antibody; TrCP120 antibody; p120 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H0E9
Immunogen : Recombinant Human Bromodomain-containing protein 8 protein (641-859AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stim µLates transcriptional activation by AR/DHTR, ESR1/NR3A1 RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively reg µLate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BRD8
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism; Microbiology; Signal transduction