MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)(2F6) , CF405S conjugate , 0.1mg / mL

Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli , including growth factors. The MEK kinases (also designated MAP kinase kinase kinases , MKKKs , MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs) , including ERK , JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1 , Raf-B , Mos , MEK kinase-1 , MEK kinase-2 , MEK kinase-3 , MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4 , and also activates the central protein kinases of the NFB pathway , CHUK and IKBKB. Additionally , MEK kinase-1 uses an E3 ligase through its PHD domain , a RING-finger-like structure , to target proteins for degradation through ubiquitination.