Laminin(A5) , CF543 conjugate , 0.1mg / mL

Laminins are large hetero-trimeric , non-collagenous glycoproteins composed of α , β , and γ chains. This MAb reacts with laminin B2/1 chain of ~210 kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components , some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN) , entactin/nidogen (EN) , collagen type IV (CIV) , and large heparan sulfate proteoglycan (HSPG) , which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity , from local discontinuities up to complete loss , are described in many types of human and animal epithelial neoplasms. This MAb stains unifor mLy all human and murine basement membranes.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.