Cytokeratin , HMW(AE-3) , CF568 conjugate , 0.1mg / mL

This MAb recognizes basic (Type II or HMW) cytokeratins , which include 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5 , 55 , 51 , 50 , 50 , 48 , 46 , 45 , and 40 kDa. MAb AE3 recognizes the 65-67 , 64 , 59 , 58 , 56 , and 52 kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail , which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung , liver carcinoma , breast cancer , and esophageal cancer.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.