MDM2(SMP14) , CF488A conjugate , 0.1mg / mL

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins , such as p53 , for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53 , diminishing its tumor suppressor function. This protein also affects the cell cycle , apoptosis , and tumorigenesis through interactions with other proteins , including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.