PDCD1 / PD1 / CD279 (Programmed Cell Death 1)(NAT105) , Biotin conjugate , 0.1mg / mL

PDCD-1 (programmed cell death-1 protein) , also designated CD279 , is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells , B-cells , and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6 , PDCD-1 is expressed by few B-cells , so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition , PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.