MA mL2 (Mastermind Like Transcriptional Coactivator 2) (MA mL2/1302) , Biotin conjugate , 0.1mg / mL

MA mL2 (mastermind-like protein 2) , also known as MAM2 , MAM3 or mLLMA mL2 , is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MA mL2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region , MA mL2 interacts with the ankyrin repeats of the Notch proteins Notch 1 , Notch 2 , Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J , a complex that can then induce HES1 gene expression. While the N-terminal domain of MA mL2 is essential for proper Notch binding , the C-terminal domain of MA mL2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MA mL2 is implicated in mucoepidermoid carcinomas , clear cell hidradenomas and benign Warthin tumors.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.