MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R) , 0.2mg / mL

The mucins are a family of highly glycosylated , secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large , secreted and cell surface glycoproteins crucial for adhesion modulation , signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4 , Mucin 5 (AC and B) , Mucins 6-8 , Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125) , encoded for by the gene MUC16 , is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain , an extracellular domain and an amino terminal domain. Mucin 16 , an ovarian cancer-associated antigen , is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.