GLRA1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : GLRA1 antibody; GLRA1_HUMAN antibody; Glycine receptor 48 kDa subunit antibody; Glycine receptor alpha 1 antibody; Glycine receptor strychnine-binding subunit antibody; Glycine receptor subunit alpha-1 antibody; Glycine receptor; alpha 1 subunit antibody; HKPX1 antibody; STHE antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P23415
Immunogen : Recombinant Human Glycine receptor subunit alpha-1 protein (23-113AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Glycine receptors are ligand-gated chloride channels (PubMed : 23994010, PubMed : 25730860). Channel opening is triggered by extracell µLar glycine (PubMed : 2155780, PubMed : 7920629, PubMed : 14551753, PubMed : 16144831 PubMed : 22715885, PubMed : 22973015, PubMed : 25973519, PubMed : 9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed : 16144831 PubMed : 9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed : 14551753). Plays an important role in the down-reg µLation of neuronal excitability (PubMed : 8298642, PubMed : 9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed : 25445488). Channel activity is potentiated by ethanol (PubMed : 25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GLRA1
Research Areas : Neuroscience