GLRB Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : GLRBGlycine receptor subunit beta antibody; Glycine receptor 58 kDa subunit antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P48167
Immunogen : Recombinant Human Glycine receptor subunit beta protein (355-472AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracell µLar glycine (PubMed : 8717357, PubMed : 15302677, PubMed : 16144831 PubMed : 22715885, PubMed : 25445488, PubMed : 11929858, PubMed : 23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed : 8717357). Plays an important role in the down-reg µLation of neuronal excitability (PubMed : 11929858, PubMed : 23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed : 25445488).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GLRB
Research Areas : Neuroscience; Signal transduction