MAGEA2 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : MAGEA2 antibody; MAGE2 antibody; MAGEA2A; antibody; MAGEA2B antibody; MAGE2 antibody; MAGEA2 antibody; Melanoma-associated antigen 2 antibody; Cancer/testis antigen 1.2 antibody; CT1.2 antibody; MAGE-2 antigen antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P43356
Immunogen : Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Reduces p53/TP53 transactivation function thro µgh recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stim µLates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conj µgating enzyme UBE2H. Proposed to act thro µgh recruitment and/or stabilization of the Ubl-conj µgating enzyme (E2) at the E3 : substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively reg µLates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAGEA2
Research Areas : Cancer; Immunology