IRS1 (Ab 312) Antibody
Volume : 100 µL
Clone Number :
Aliases : HIRS 1 antibody; HIRS1 antibody; Ins µLin receptor substrate 1 antibody; IRS 1 antibody; IRS-1 antibody; IRS1 antibody; IRS1_HUMAN antibody; OTTHUMP00000164234 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P35568
Immunogen : SyntheVolumed non-phosphopeptide derived from Human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A).
Raised in : Rabbit
Species Reactivity : Human, Mouse, Rat
Tested Applications : ELISA, WB, IHC, IF; WB : 1 : 500-1 : 3000, IHC : 1 : 50-1 : 100, IF : 1 : 100-1 : 500
Background : May mediate the control of various cell µLar processes by ins µLin. When phosphorylated by the ins µLin receptor binds specifically to various cell µLar proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the reg µLatory p85 subunit By similarity.
Araki E., Diabetes 42 : 1041-1054(1993).
Nishiyama M., Biochem. Biophys. Res. Commun. 183 : 280-285(1992).
The MGC Project Team; Genome Res. 14 : 2121-2127(2004)
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conj µgate : Non-conj µgated
Buffer : Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IRS1
Research Areas : Neuroscience?Cancer?Cardiovasc µLar;Tags & Cell Markers;Metabolism;Signal transduction