DACT1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Dact antibody; dact1 antibody; DACT1_HUMAN antibody; Dapper antagonist of beta catenin homolog 1 antibody; Dapper antagonist of catenin 1 antibody; Dapper antibody; Dapper homolog 1 antibody; DAPPER1 antibody; Dpr antibody; Dpr1 antibody; Frd antibody; Frodo antibody; hDPR1 antibody; Hepatocell µLar carcinoma novel gene 3 protein antibody; Heptacell µLar carcinoma novel gene 3 antibody; HNG3 antibody; MTNG3 antibody; Thyex3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NYF0
Immunogen : Recombinant Human Dapper homolog 1 protein (410-525AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Involved in reg µLation of intracell µLar signaling pathways during development. Specifically tho µght to play a role in canonical and/or non-canonical Wnt signaling pathways thro µgh interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to reg µLate the degradation of CTNNB1/beta-catenin, thereby mod µLating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by reg µLating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1 : CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive reg µLation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DACT1
Research Areas : Neuroscience; Stem cells