botA Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : botA antibody; atx antibody; bonTBot µLinum neurotoxin type A antibody; BoNT/A antibody; Bontoxilysin-A antibody; BOTOX antibody; Bot µLinum neurotoxin type A1) [Cleaved into : Bot µLinum neurotoxin A light chain antibody; LC antibody; EC 3.4.24.69); Bot µLinum neurotoxin A heavy chain antibody; HC)] antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Clostridium bot µLinum
UniProt ID : P0DPI0
Immunogen : Recombinant Clostridium bot µLinum Bot µLinum neurotoxin type A protein (1-436AA)
Raised in : Rabbit
Species Reactivity : Clostridium bot µLinum
Tested Applications : ELISA
Background : Inhibits acetylcholine release. The bot µLinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release res µLts in flaccid paralysis, with frequent heart or respiratory failure.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : botA
Research Areas : Others