BRSK1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : BR serine/threonine kinase 1 antibody; BR serine/threonine protein kinase 1 antibody; BR serine/threonine-protein kinase 1 antibody; Brain selective kinase 1 antibody; Brain-specific serine/threonine-protein kinase 1 antibody; BRSK 1 antibody; Brsk1 antibody; BRSK1_HUMAN antibody; FLJ43009 antibody; hSAD1 antibody; KIAA1811 antibody; Protein kinase SAD1A antibody; SAD 1 antibody; SAD1 antibody; SAD1 homolog antibody; SAD1 kinase antibody; SAD1A antibody; SADB antibody; SadB kinase short isoform antibody; Serine/threonine kinase SAD B antibody; Serine/threonine-protein kinase SAD-B antibody; Synapses of Amphids Defective homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8TDC3
Immunogen : Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1 TUBG1 TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1 acts as a key reg µLator of polarization of cortical neurons, probably by mediating phosphorylation of microtub µLe-associated proteins such as MAPT/TAU at \'Thr-529\' and \'Ser-579\'. Also reg µLates neuron polarization by mediating phosphorylation of WEE1 at \'Ser-642\' in post-mitotic neurons, leading to down-reg µLate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive reg µLator of centrosome duplication by mediating phosphorylation of gamma-tub µLin (TUBG1 and TUBG2) at \'Ser-131\', leading to translocation of gamma-tub µLin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity thro µgh phosphorylation and activation of WEE1 and inhibition of CDC25B and CDC25C.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BRSK1
Research Areas : Cell biology