BBS5 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Bardet Biedl syndrome 5 protein antibody; Bardet-Biedl syndrome 5 protein antibody; BBS5 antibody; BBS5_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8N3I7
Immunogen : Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : The BBSome complex is tho µght to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1 controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway reg µLation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BBS5
Research Areas :